期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 37, 页码 18732-18737出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1900872116
关键词
behavioral variability; intrinsic brain fluctuations; dopaminergic midbrain; risky decision making; real-time fMRI
资金
- Singapore Institute of Management
- Wellcome Sir Henry Dale Fellowship [211155/Z/18/Z]
- Jacobs Foundation [2017-1261-04]
- Medical Research Foundation
- 2018 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation [27023]
- Wellcome Trust [098362/Z/12/Z, 203147/Z/16/Z]
- Medical Research Council Career Development Award [MR/N02401X/1]
- 2018 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation, PS Fund [27674]
- UCL
- Max Planck Society
- MRC [MR/L012936/1, MR/N02401X/1] Funding Source: UKRI
Human behavior is surprisingly variable, even when facing the same problem under identical circumstances. A prominent example is risky decision making. Economic theories struggle to explain why humans are so inconsistent. Resting-state studies suggest that ongoing endogenous fluctuations in brain activity can influence low-level perceptual and motor processes, but it remains unknown whether endogenous fluctuations also influence high-level cognitive processes including decision making. Here, using real-time functional magnetic resonance imaging, we tested whether risky decision making is influenced by endogenous fluctuations in blood oxygenation level-dependent (BOLD) activity in the dopaminergic midbrain, encompassing ventral tegmental area and substantia nigra. We show that low prestimulus brain activity leads to increased risky choice in humans. Using computational modeling, we show that increased risk taking is explained by enhanced phasic responses to offers in a decision network. Our findings demonstrate that endogenous brain activity provides a physiological basis for variability in complex human behavior.
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