Analysis of FAM19A2/TAFA-2 function

FAM19A2/TAFA-2, a member of the chemokine CC family, shares 31% sequence identity with MIP-1 alpha, which is known to elevate body temperature and reduce food intake. A single administration of 250 pM of FAM19A2/TAFA-2 to the third ventricle of mice just before the initiation of dark period increased food intake and meal number significantly, but reduced meal size during the dark period. The respiratory exchange rate and energy expenditure were increased significantly during the dark period, while the ambulatory count and vertical activity were not affected. These data suggest that FAM19A2/TAFA-2 participates in the regulation of food intake and metabolic activities.