期刊
PHYSIOLOGICAL REVIEWS
卷 100, 期 1, 页码 145-169出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00030.2018
关键词
cancer; chromatin deacetylase; epigenetics; SIRT6
类别
资金
- National Institutes of Health [R01CA235412, R01GM128448, R21ES025638]
- Broad-ISF Consortium
- Harvard College Office of Undergraduate Research and Fellowships
- American Cancer Society
Mammalian sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging. In this review, we describe the multiple roles of SIRT6, a chromatin deacylase with unique and important functions in maintaining cellular homeostasis. We attempt to provide a framework for such different functions, for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.
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