期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 27, 期 -, 页码 162-166出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2019.05.041
关键词
OCTA; Low fluence; Photodynamic therapy; CSCR; Chorioretinopathy
类别
Background: To evaluate the efficacy of optical coherence tomography angiography (OCTA) in identifying changes in the choriocapillaris layer after low-fluence verteporfin photodynamic therapy (vPDT) in patients affected by chronic central serous chorioretinopathy (CSCR). Methods: Low-fluence vPDT was performed on 28 eyes of 27 patients with CSCR. All patients underwent the following tests at baseline and 6 months after treatment: best corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT and OCTA. Results: Subretinal fluid was completely absorbed in 18 of the 28 affected eyes (64.3%) after low-fluence vPDT (responders), and incompletely absorbed in 10 eyes (35.7%) (non responders). BCVA was significantly improved (p = 0.006) whereas central foveal thickness and choroidal foveal thickness were significantly decreased (p = 0.001 and p = 0.00 respectively) 6 months after treatment in responders. Conclusions: OCTA revealed a different pattern of vascular remodeling of the choriocapillaris between CSC patients who responded and those who did not respond to low-fluence vPDT.
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