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BIOCHEMISTRY (2009)
The impact of left ventricular assist device-induced left ventricular unloading on the myocardial renin-angiotensin-aldosterone system: therapeutic consequences?
Stefan Klotz et al.
EUROPEAN HEART JOURNAL (2009)
The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats
Marcelo C. Leal et al.
JOURNAL OF ANATOMY (2009)
Soluble Angiotensin-Converting Enzyme 2 in Human Heart Failure: Relation With Myocardial Function and Clinical Outcomes
Slava Epelman et al.
JOURNAL OF CARDIAC FAILURE (2009)
Structure of human Endothelin-converting Enzyme I Complexed with Phosphoramidon
Henk Schulz et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
The kallikrein-kinin system in health and in diseases of the kidney
Masao Kakoki et al.
KIDNEY INTERNATIONAL (2009)
Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity
Cedric Claperon et al.
BIOCHEMICAL JOURNAL (2008)
Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme
Jean M. Watermeyer et al.
BIOCHEMISTRY (2008)
The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme
Hester G. O'Neill et al.
BIOLOGICAL CHEMISTRY (2008)
Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema
R. M. Fryer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Effects of Carperitide on the Long-Term Prognosis of Patients With Acute Decompensated Chronic Heart Failure-The PROTECT Multicenter Randomized Controlled Study-
Noritake Hata et al.
CIRCULATION JOURNAL (2008)
Angiotensin-(1-7): Pharmacological properties and pharmacotherapeutic perspectives
Dilek Iusuf et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
A protein complex in the brush-border membrane explains a Hartnup disorder allele
Sonja Kowalczuk et al.
FASEB JOURNAL (2008)
Orally active aminopeptidase A inhibitors reduce blood pressure -: A new strategy for treating hypertension
Laurence Bodineau et al.
HYPERTENSION (2008)
Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo
Sebastien Fuchs et al.
HYPERTENSION (2008)
Angiotensin-converting enzyme inhibitors and angioedema - Estimating the risk
Michael A. Weber et al.
HYPERTENSION (2008)
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
Jose A. Hernandez Prada et al.
HYPERTENSION (2008)
Discovery and Validation of Novel Peptide Agonists for G-protein-coupled Receptors
Ronen Shemesh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Detection of soluble angiotensin-converting enzyme 2 in heart failure
Slava Epelman et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)
Angiotensin metabolites can stimulate receptors of the Mas-related genes family
Florian Gembardt et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2008)
The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets
Rodrigo Araujo Fraga-Silva et al.
MOLECULAR MEDICINE (2008)
Telmisartan, ramipril, or both in patients at high risk for vascular events
Salim Yusuf et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A
Yoshikuni Goto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The renin-angiotensin aldosterone system: Pathophysiological role and pharmacologic inhibition
Steven A. Atlas
JOURNAL OF MANAGED CARE PHARMACY (2007)
ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts
Justin L. Grobe et al.
CLINICAL SCIENCE (2007)
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV
Christian Oefner et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2007)
Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla
Patricia Maria Ferreira et al.
REGULATORY PEPTIDES (2007)
The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380
Hazel R. Corradi et al.
BIOCHEMISTRY (2007)
Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor
Inmaculada C. Villar et al.
CARDIOVASCULAR RESEARCH (2007)
Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
Walkyria Oliveira Sampaio et al.
HYPERTENSION (2007)
Angiotensin-(1-7): Pharmacology and new perspectives in cardiovascular treatments
Aaron J. Trask et al.
CARDIOVASCULAR DRUG REVIEWS (2007)
ACE phenotyping as a first step toward personalized medicine for ACE inhibitors. Why does ACE genotyping not predict the therapeutic efficacy of ACE inhibition?
A. H. Jan Danser et al.
PHARMACOLOGY & THERAPEUTICS (2007)
Essential role for collectrin in renal amino acid transport
Ursula Danilczyk et al.
NATURE (2006)
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study
Gillian I. Rice et al.
HYPERTENSION (2006)
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors
Aloysius T. Nchinda et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme
Aloysius T. Nchinda et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
A randomized, double-blind, placebo-controlled, parallel-group study to assess the efficacy and safety of dual ACE/NEP inhibitor GW660511X in mild-to-moderate hypertensive patients
A. G. Johnson et al.
JOURNAL OF HUMAN HYPERTENSION (2006)
Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design
HR Corradi et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans
M Azizi et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
The first preclinical pharmacotoxicological safety assessment of CGS 35601, a triple vasopeptidase inhibitor, in chronically instrumented, conscious, and unrestrained spontaneously hypertensive rats
P Daull et al.
DRUG AND CHEMICAL TOXICOLOGY (2006)
Endothelin receptor antagonists
Sophie Motte et al.
PHARMACOLOGY & THERAPEUTICS (2006)
Mechanism of vasopeptidase inhibitor-induced plasma extravasation: Comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406
AC Sulpizio et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats
P Daull et al.
AMERICAN JOURNAL OF HYPERTENSION (2005)
Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
AM Hawkridge et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor
EA Tallant et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
F Li et al.
SCIENCE (2005)
Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
DW Lambert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
In vivo characterization of the angiotensin-(1-7)-induced dopamine and γ-aminobutyric acid release in the striatum of the rat
B Stragier et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Biology of natriuretic peptides and their receptors
KN Pandey
PEPTIDES (2005)
Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats
PE Walters et al.
HYPERTENSION (2005)
G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
E Kostenis et al.
CIRCULATION (2005)
Molecular evidence of tissue renin-angiotensin systems: A focus on the brain
K Sakai et al.
CURRENT HYPERTENSION REPORTS (2005)
Multicenter prospective investigation on efficacy and safety of carperitide for acute heart failure in the 'real world' of therapy
M Suwa et al.
CIRCULATION JOURNAL (2005)
International union of pharmacology.: XLV.: Classification of the kinin receptor family:: from molecular mechanisms to pathophysiological consequences
LMF Leeb-Lundberg et al.
PHARMACOLOGICAL REVIEWS (2005)
Dual angiotensin II and endothelin a receptor antagonists:: Synthesis of 2′-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics
N Murugesan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Second-generation inhibitors for the metalloprotease neprilysin based on bicyclic heteroaromatic scaffolds: Synthesis, biological activity, and X-ray crystal-structure analysis
S Sahli et al.
HELVETICA CHIMICA ACTA (2005)
Selective angiotensin-converting enzyme c-domain inhibition is sufficient to prevent angiotensin I-induced vasoconstriction
JHM van Esch et al.
HYPERTENSION (2005)
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
P Towler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice
S Fuchs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structural analysis of neprilysin with various specific and potent inhibitors
C Oefner et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Omapatrilat and enalapril in patients with hypertension: The omapatrilat cardiovascular treatment vs. enalapril (OCTAVE) trial
OB Kostis et al.
AMERICAN JOURNAL OF HYPERTENSION (2004)
Effect of single doses of SLV306, an inhibitor of both neutral enclopepticlase and enclothelin-converting enzyme, on pulmonary pressures in congestive heart failure
K Dickstein et al.
AMERICAN JOURNAL OF CARDIOLOGY (2004)
Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits Gαq protein signaling but not ERK activation
JL Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance
Z Abassi et al.
PHARMACOLOGY & THERAPEUTICS (2004)
Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: A potential treatment of salt-dependent hypertension
MC Fournie-Zaluski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
GI Rice et al.
BIOCHEMICAL JOURNAL (2004)
Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney
SVB Pinheiro et al.
HYPERTENSION (2004)
Contribution of molecular modeling and site-directed mutagenesis to the identification of a new residue, glutamate 215, involved in the exopeptidase specificity of aminopeptidase A
R Rozenfeld et al.
BIOCHEMISTRY (2003)
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
WH Li et al.
NATURE (2003)
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors:: the CHARM-Alternative trial
CB Granger et al.
LANCET (2003)
Recent clinical trials with omapatrilat: New developments
A Zanchi et al.
CURRENT HYPERTENSION REPORTS (2003)
Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin - Insights from selective inhibitors
D Georgiadis et al.
CIRCULATION RESEARCH (2003)
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
RAS Santos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives
SJ Veerasingham et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats
JW Wright et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2003)
Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
R Natesh et al.
NATURE (2003)
AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium
G Wiemer et al.
HYPERTENSION (2002)
Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-Arginine9-bradykinin
G Molinaro et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Discovery of Ν-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists
N Murugesan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Comparison of omapatrilat chronic and enalapril in patients with heart failure - The omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE)
M Packer et al.
CIRCULATION (2002)
Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A
R Rozenfeld et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
AS Maisel et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides
J Cotton et al.
BIOCHEMISTRY (2002)
Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats
Q Pu et al.
JOURNAL OF HYPERTENSION (2002)
Angiotensin 1-9 and 1-7 release in human heart -: Role of cathepsin A
HL Jackman et al.
HYPERTENSION (2002)
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
C Vickers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):: a randomised trial against atenolol
B Dahlöf et al.
LANCET (2002)
The angiotensin II AT2 receptor is an AT1 receptor antagonist
S AbdAlla et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Bradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade
B Tom et al.
HYPERTENSION (2001)
Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
K Shirotani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Metabolic regulation of brain Aβ by neprilysin
N Iwata et al.
SCIENCE (2001)
A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP)
D Bur et al.
PROTEIN ENGINEERING (2001)
Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation
MMGM Thunnissen et al.
NATURE STRUCTURAL BIOLOGY (2001)
Endothelin system: The double-edged sword in health and disease
RM Kedzierski et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)
A human homolog of angiotensin-converting enzyme - Cloning and functional expression as a captopril-insensitive carboxypeptidase
SR Tipnis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
S AbdAlla et al.
NATURE (2000)
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
M Donoghue et al.
CIRCULATION RESEARCH (2000)
Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure.
WS Colucci et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Regulation and intracellular trafficking pathways of the endothelin receptors
T Bremnes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Vasopeptidase inhibition has potent effects on blood pressure and resistance arteries in stroke-prone spontaneously hypertensive rats
HD Intengan et al.
HYPERTENSION (2000)
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial - the Losartan Heart Failure Survival Study ELITE II
B Pitt et al.
LANCET (2000)
Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma
A Kuoppala et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)
Structure of human neutral endopeptidase (neprilysin) complexed with phosphoramidon
C Oefner et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
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