期刊
PARKINSONISM & RELATED DISORDERS
卷 66, 期 -, 页码 269-271出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2019.08.018
关键词
Parkinson's disease; Phase-amplitude coupling; Deep brain stimulation; Electroencephalography
资金
- National Institutes of Health [R01-NS090913-01]
- Bachman-Strauss Dystonia and Parkinson Foundation
- Neurosurgery Research and Education Foundation Medical Student Summer Research Fellowship
Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude. Here we show by non-invasive scalp electroencephalography that withdrawal of chronic DBS elevates phase-amplitude coupling, in proportion to the worsening of contralateral rigidity.
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