期刊
PANCREAS
卷 48, 期 8, 页码 1026-1031出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPA.0000000000001377
关键词
intraductal papillary mucinous neoplasm; pancreatic cyst; interleukin-1 beta; prostaglandin E2; biomarker; dysplasia; IPMN; intraductal papillary mucinous neoplasm; IL-1 beta; interleukin-1 beta; PGE2; prostaglandin E2; CA 19-9; carbohydrate antigen 19-9; HGD; high-grade dysplasia; AUC; area under the curve; NSAIDs; nonsteroidal anti-inflammatory drugs; Sn; sensitivity; Sp; specificity; PPV; positive predictive value; NPV; negative predictive value; Acc; accuracy; ROC; receiver operating characteristic; CEA; carcinoembryonic antigen
资金
- Indiana Clinical and Translational Sciences Institute [UL1TR001108]
- National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award [NIH/NCRR RR020128]
Objectives We sought to determine if interleukin (IL)-1 beta and prostaglandin E2 (PGE2) (inflammatory mediators in pancreatic fluid) together with serum carbohydrate antigen (CA) 19-9 could better predict intraductal papillary mucinous neoplasm (IPMN) dysplasia than individual biomarkers alone. Methods Pancreatic cyst fluid (n = 92) collected via endoscopy or surgery (2003-2016) was analyzed for PGE2 and IL-1 beta (enzyme-linked immunosorbent assay). Patients had surgical pathology-proven IPMN. Threshold values (PGE2 [>1100 pg/mL], IL-1 beta [>20 pg/mL], and serum CA 19-9 [>36 U/mL]) were determined. Results Levels of IL-1 beta were higher in high-grade dysplasia (HGD)/invasive-IPMN (n = 42) compared with low/moderate IPMN (n = 37) (median [range], 54.6 [0-2671] vs 5.9 [0-797] pg/mL; P < 0.001; area under curve [AUC], 0.766). Similarly, PGE2 was higher in HGD/invasive IPMN (n = 45) compared with low/moderate IPMN (n = 47) (median [range], 1790 [20-15,180] vs. 140 [10-14,630] pg/mL; P < 0.001; AUC, 0.748). Presence of elevated PGE2 and IL-1 beta (AUC, 0.789) provided 89% specificity and 82% positive predictive value (PPV) for HGD/invasive IPMN. Elevated levels of all 3 provided 100% specificity and PPV for HGD/invasive IPMN. Conclusions Cyst fluid PGE2, IL-1 beta, and serum CA 19-9 in combination optimize specificity and PPV for HGD/invasive IPMN and may help build a panel of markers to predict IPMN dysplasia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据