期刊
BASIC RESEARCH IN CARDIOLOGY
卷 111, 期 6, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-016-0586-x
关键词
Cardiomyocyte signaling pathways; Cardioprotection; Cardiovascular disease; Co-morbidities; Drug targeting; Endothelial permeability; Extracellular RNA (eRNA); Heart regeneration; Induced pluripotent stem cells; Ischemia-reperfusion injury; Lipid metabolism; MicroRNAs (miRNAs); Mitochondria; Remote ischemic conditioning
资金
- German Research Foundation (DFG, Bonn, Germany)
- Peter und Traudl Engelhorn-Stiftung'' (Weilheim, Germany)
- Russian Government Program for competitive growth of Kazan Federal University, Kazan (Russian Federation)
- Ministerio de Economia y Competitividad [SAF2013-46058-R]
- Comunidad de Madrid/Fondo Social Europeo [S2010/BMD-2542 Consepoc-CM'']
- Red de Cardiovascular [RD12/0042/0065]
- Deutsche Forschungsgemeinschaft (DFG) [BE 1977/9-1, SFB1123]
- DFG [EXC 1010]
- Else Kroner-Fresenius Stiftung (EKFS) [2014_A216]
- Danish Council for Strategic Research [11-115818]
- Trygfonden
- NovoNordisk Fonden
- NIH [HL075677, HL081863]
- Hungarian Scientific Research Fund [OTKA ANN 107803, OTKA K-105555]
- Interdisciplinary Centre for Clinical Research Erlangen (IZKF) [J42, F3]
- Emerging Fields Initiative Cell Cycle in Disease and Regeneration (CYDER)'' (Friedrich-Alexander-University Erlangen-Nurnberg)
- Deutsche Forschungsgemeinschaft [SFB 1039/A6]
- Winetech, National Research Foundation
- Interdisciplinary Centre for Clinical Research IZKF Aachen
- Medical Research Council (UK) [G1000737]
- Guy's and St Thomas' Charity [R060701, R100404]
- British Heart Foundation [TG/15/1/31518]
- UK Department of Health through the National Institute for Health Research Biomedical Research Centre award
- Khoo Postdoctoral Fellowship Award from the Estate of Tan Sri Khoo Teck Puat, Singapore [Duke-NUS-KPFA/2016/0010]
- German Research Foundation (Cluster of excellence REBIRTH) Grant
- Duke-NUS Medical School Singapore
- Goh foundation
- Singapore National Research Foundation (NRF) fellowship [NRF-NRFF2016-01]
- German Research Council DFG [INST 2105/24-1, SCHN 430/6-2]
- German Research Foundation (DFG, Bonn, Germany) [Schu843/9-1]
- National Medical Research Council [NMRC/BNIG/1074/2012]
- Goh Foundation/Duke-NUS Medical School [GCR/2013/008, GCR/2013/010, GCR/2013/011]
- SingHealth Foundation [SHF/FG569P/2014, SHF/FG630S/2014]
- Biomedical Research Council Singapore [BMRC13/1/96/19/686A]
- Singapore National Research Foundation (NRF) Competitive Research Program [NRF-CRP-2008-02]
- Cardiometabolic Board of the Biomedical Research Centre at UCL
- NIHR UK
- Grants-in-Aid for Scientific Research [26461133] Funding Source: KAKEN
- British Heart Foundation [SP/12/5/29574, FS/13/2/29892, TG/15/1/31518] Funding Source: researchfish
- Medical Research Council [G1000737, MR/K002066/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10164] Funding Source: researchfish
- Rosetrees Trust [M274] Funding Source: researchfish
- MRC [G1000737, MR/K002066/1] Funding Source: UKRI
In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemiareperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.
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