期刊
ORGANIC LETTERS
卷 21, 期 16, 页码 6432-6436出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02333
关键词
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资金
- NSFC [81773598, 81573311]
- Young Scholars Program of Shandong University [2016WLJH31]
- Fundamental Research Funds of Shandong University [2018JC004]
- Taishan Scholars Program of Shandong Province
- University of Nebraska's Collaboration Initiative grant program
Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered peptide specialists. Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.
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