期刊
ORGANIC LETTERS
卷 21, 期 17, 页码 6750-6755出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02375
关键词
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资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02-06]
The asymmetric organocatalytic cascade reaction of cyclic beta-oxo aldehydes to 2-hydroxycinnamaldehydes is developed. The bifunctional tertiary amine-thiourea catalyst was used in a rationally designed multiple catalysis where the asymmetric iminium catalysis and thiourea anion-binding catalysis were combined by carboxylate anion as a ternary catalytic system to form a quinary catalyst-substrate complex, providing an efficient protocol for the construction of enantioenriched spiro-bridged or cagelike polyheterocyclic compounds. The reuse of catalysts was also successfully realized.
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