期刊
ORGANIC LETTERS
卷 21, 期 19, 页码 7908-7913出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02899
关键词
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资金
- Knut and Alice Wallenberg Foundation [KAW2016.0153]
- European Research Council [714737]
- Department of Organic Chemistry at Stockholm University
The direct preparation of ketones from carboxylate anions is greatly limited by the required use of organolithium reagents or activated acyl sources that need to be independently prepared. Herein, a specific magnesium amide additive is used to activate and control the addition of more tolerant Grignard reagents to carboxylate anions. This strategy enables the modular synthesis of ketones from CO2 and the preparation of isotopically labeled pharmaceutical building blocks in a single operation.
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