期刊
ORGANIC LETTERS
卷 21, 期 20, 页码 8153-8157出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02412
关键词
-
资金
- National Natural Science Foundation of China [21232006, 21642002]
- Chinese Academy of Sciences
A novel Pd(II)-catalyzed reductive asymmetric cyclization of N-tosyl-tethered 1,7-enynes using ethanol as a hydrogen source is reported. This reaction provides facile ways for the synthesis of two types of 1,2,3,4-tetrahydroquinolines possessing a chiral quaternary carbon center in high yields with excellent enantioselectivities. The obtained products can also be converted to other chiral functionalized tetrahydroquinolines efficiently. The procedure involves a palladium catalyzed intramolecular hydropalladation/1,4-addition or beta-heteroatom elimination cascade process.
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