期刊
ORGANIC LETTERS
卷 21, 期 18, 页码 7238-7243出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02448
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-
资金
- Mercator Research Center Ruhr (MERCUR) [Pr-2016-0010]
Isocyanide multicomponent reactions play a prominent role in drug discovery. This chemistry has hardly been investigated for compatibility with DNA-encoded combinatorial synthesis. The Ugi, Ugi-azide, and Groebke-Blackburn-Bienayme reactions are well-tolerated by DNA on the solid phase and show a broad scope. However, an oxadiazole-forming variant of the Ugi reaction caused DNA depurination, requiring a more stable hexathymidine DNA for encoded library synthesis. Cheminformatic analysis revealed that isocyanide multicomponent-reaction-based encoded libraries cover a diverse chemical space.
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