期刊
ORGANIC LETTERS
卷 21, 期 20, 页码 8290-8294出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03053
关键词
-
资金
- NSF [CHE-1362111]
- University of Iowa training program in Pharmacological Sciences [T32 GM067795]
Increased versatility of intermolecular radical addition to imino acceptors via photoredox catalysis is reported. Primary and secondary radicals, generated via visible-light photocatalysis from alkyl biscatecholatosilicates with organocatalyst 4CzIPN, add successfully to both aromatic and aliphatic N-acylhydrazones in the presence of MgCl2. With N-benzoylhydrazones, a simple reductive cleavage of the N-N bond of the hydrazine adduct furnishes the free amine. Synthetic utility is exemplified in a synthetic application toward repaglinide, a clinically important hypoglycemic agent.
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