期刊
ORGANIC LETTERS
卷 21, 期 18, 页码 7274-7278出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02525
关键词
-
资金
- National Institutes of Health, National Cancer Institute [R01CA172310]
- National Institute of General Medical Sciences [P41GM086210]
- Debbie and Sylvia DeSantis Chair professorship
Quorum sensing (QS) plays a critical role in the regulation of bacterial pathogenesis. Doscadenamide A (1a) was isolated from a marine cyanobacterium, its structure elucidated by NMR, and its activity linked to QS induction. The total synthesis of 1a was developed, and the absolute configuration confirmed through comparison of the isolated natural product with synthetic diastereomers. Our preliminary investigation indicated that 1a could activate QS signaling in a LasR-dependent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据