期刊
ONCOGENE
卷 39, 期 3, 页码 677-689出版社
SPRINGERNATURE
DOI: 10.1038/s41388-019-1005-1
关键词
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资金
- National Natural Science Foundation of China [31801115, 61803129, 61603116, 61873075]
- China Postdoctoral Science Foundation [2018M631943, 2018M641860]
- China Postdoctoral Science Special Foundation [2019T120280]
- Hei Long Jiang Postdoctoral Foundation [LBH-Z17110, LBH-Z17218]
- General Program of Natural Science Foundation of Heilongjiang Province [H2016055]
- Fundamental Research Funds for the Provincial Universities [2017JCZX54, 2017JCZX51]
- Heilongjiang Provincial Health and Family Planning Commission of Science Foundation [2018476, 2018477]
- Heilongjiang Provincial planning office key subjects [GBB1318066]
Epigenetic modifications play critical roles in modulating gene expression, yet their roles in regulatory networks in human cell lines remain poorly characterized. We integrated multiomics data to construct directed regulatory networks with nodes and edges labeled with chromatin states in human cell lines. We observed extensive association of diverse chromatin states and network motifs. The gene expression analysis showed that diverse chromatin states of coherent type-1 feedforward loop (C1-FFL) and incoherent type-1 feedforward loops (I1-FFL) contributed to the dynamic expression patterns of targets. Notably, diverse chromatin state compositions could help C1- or I1-FFL to control a large number of distinct biological functions in human cell lines, such as four different types of chromatin state compositions cooperating with K562-associated C1-FFLs controlling regulation of cytokinesis, G1/S transition of mitotic cell cycle, DNA recombination, and telomere maintenance, respectively. Remarkably, we identified six chromatin state-marked C1-FFL instances (HCFC1-NFYA-ABL1, THAP1-USF1-BRCA2, ZNF263-USF1-UBA52, MYC-ATF1-UBA52, ELK1-EGR1-CCT4, and YY1-EGR1-INO80C) could act as prognostic biomarkers of acute myelogenous leukemia though influencing cancer-related biological functions, such as cell proliferation, telomere maintenance, and DNA recombination. Our results will provide novel insight for better understanding of chromatin state-mediated gene regulation and facilitate the identification of novel diagnostic and therapeutic biomarkers of human cancers.
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