期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 39, 期 1-3, 页码 439-452出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2019.1670839
关键词
Radiosensitization; DNA damage repair; 3 '-ethynylcytidine (ECyd); apoptosis; cell cycle checkpoint
The combination of low dose of radiation and an anticancer drug is a potent strategy for cancer therapy. Nucleoside analogs are known to have a radiosensitizing effects via the inhibition of DNA damage repair after irradiation. Certain types of nucleoside analogs have the inhibitory effects on RNA synthesis, but not DNA synthesis, with multiple functions in cell cycle modulation and apoptosis. In this review, the most up-to-date findings regarding radiosensitizing nucleoside analogs will be discussed, focusing especially on the mechanisms of action.
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