期刊
NEUROSCIENCE LETTERS
卷 709, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2019.134368
关键词
Prenatal stress; Oxidative stress; Heat shock; Neurodevelopment; Embryonic brain; Neuropsychiatric disorders
资金
- Roy J. Carver Charitible Trust
- Ida P. Haller Chair in Child Psychiatry
- University of Iowa Graduate College
- National Institute for Environmental Health Sciences through the University of Iowa Environmental Health Sciences Research Center [NIEHS/NIH P30 ES005605]
- Nellie Ball Trust
Development of the brain prenatally is affected by maternal experience and exposure. Prenatal maternal psychological stress changes brain development and results in increased risk for neuropsychiatric disorders. In this review, multiple levels of prenatal stress mechanisms (offspring brain, placenta, and maternal physiology) are discussed and their intersection with cellular stress mechanisms explicated. Heat shock factors and oxidative stress are closely related to each other and converge with the inflammation, hormones, and cellular development that have been more deeply explored as the basis of prenatal stress risk. Increasing evidence implicates cellular stress mechanisms in neuropsychiatric disorders associated with prenatal stress including affective disorders, schizophrenia, and child-onset psychiatric disorders. Heat shock factors and oxidative stress also have links with the mechanisms involved in other kinds of prenatal stress including external exposures such as environmental toxicants and internal disruptions such as preeclampsia. Integrative understanding of developmental neurobiology with these cellular and physiological mechanisms is necessary to reduce risks and promote healthy brain development.
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