期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 104, 期 -, 页码 11-25出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.06.030
关键词
Optimal; Neuro-mental relationship; Inverted-U shape model; Psychiatric diagnosis; RDoC
资金
- European Union's Horizon 2020 Framework Programme for Research and Innovation [785907]
- Ministry of Science and Technology of China
- National Key R&D Program of China [2016YFC1306700]
- Canadian Institute of Health Research (CIHR)
- Physicians' Services Incorporated Foundation (PSI)
- Michael Smith Foundation-Canada Institute of Health Research (EJLB-CIHR)
- National Natural Science Foundation of China [31271195]
Traditionally, studies emphasize differences in neural measures between pathological and healthy groups, assuming a binary distinction between the groups, and a linear relationship between neural measures and symptoms. Here, we present four examples that show a continuous relation across the divide of normal and pathological states between neural measures and mental functions. This relation can be characterized by a nonlinear inverted-U shaped curve. Along this curve, mid-range or average expression of a neural measure is associated with optimal function of a mental feature (in healthy states), whereas extreme expression, either high or low, is associated with sub-optimal function, and occurs in different neural disorders. Neural expression between the optimal or intermediate and pathological or extreme values is associated with sub-optimal function and atrisk mental states. Thus, this model of neuro-mental relationship can be summarized as average is good, extremes are bad. By focussing on neuro-mental relationships, this model can facilitate the transition of psychiatry from a categorical to a dimensional and individualized approach needed in the era of precision medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据