期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 32, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/nmo.13699
关键词
gastric emptying; gastroparesis; motility; pediatric gastroenterology
资金
- National Institutes of Health (NIH) [U01 DK112194, R01 NR016786]
- Daffy's Foundation
- United States Department of Agriculture/Agriculture Research Service [6250-51000-043]
- [P30 DK056338]
- [K23 DK101688]
- [R03 DK117219]
Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP-specific pediatric reported outcome measures. Purpose The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co-morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric-focused therapies.
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