期刊
AUTOPHAGY
卷 12, 期 7, 页码 1073-1082出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2016.1179410
关键词
apoptosis; autophagy; immunity; mitochondrial function; sepsis
类别
资金
- Hong Kong Research Grant Council-General Research Fund [464212, 24115815]
- Food and Health Bureau-Commissioned Research on Control of Infectious Diseases [CU-15-B2]
- Food and Health Bureau-Health and Medical Research Fund [15140132]
Autophagy is one of the innate immune defense mechanisms against microbial challenges. Previous in vitro and in vivo models of sepsis demonstrated that autophagy was activated initially in sepsis, followed by a subsequent phase of impairment. Autophagy modulation appears to be protective against multiple organ injuries in these murine sepsis models. This is achieved in part by preventing apoptosis, maintaining a balance between the productions of pro- and anti-inflammatory cytokines, and preserving mitochondrial functions. This article aims to discuss the role of autophagy in sepsis and the therapeutic potential of autophagy enhancers.
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