期刊
NEUROBIOLOGY OF AGING
卷 84, 期 -, 页码 158-165出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2019.08.031
关键词
Cerebrovascular disease; Stroke; Ischemic stroke; Intracranial hemorrhage; Magnetic resonance imaging; Epidemiology
资金
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- Mutuelle Generale de l'Education Nationale
- Institut de la Longevite
- Conseil Regionaux of Aquitaine
- Conseil Regionaux of Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- European Research Council
- European Union
- Joint Programme of Neurodegenerative Disease research
- European Union [643417, 667375, 640643]
- Initiative of Excellence of Bordeaux University
- Agence Nationale pour le Recherche
- European Research Council (ERC) [640643] Funding Source: European Research Council (ERC)
Commonly observed in older community persons, dilated perivascular spaces (dPVSs) are thought to represent an emerging MRI marker of cerebral small vessel disease, but their clinical significance is uncertain. We examined the longitudinal relationship of dPVS burden with risk of incident stroke, ischemic stroke, and intracerebral hemorrhage (ICH) in the 3C-Dijon population-based study (N = 1678 participants, mean age 72.7 +/- 4.1 years) using Cox regression. dPVS burden was studied as a global score and according to dPVS location (basal ganglia, white matter, hippocampus, brainstem) at the baseline. During a mean follow-up of 9.1 +/- 2.6 years, 66 participants suffered an incident stroke. Increasing global dPVS burden was associated with a higher risk of any incident stroke (hazard ratio [HR], 1.24; 95% CI, [1.06-1.45]) and of incident ICH (HR, 3.12 [1.78-5.47]), adjusting for sex and intracranial volume. Association with ICH remained significant after additionally adjusting for vascular risk factors and for other cerebral small vessel disease MRI markers. High dPVS burden in basal ganglia and hippocampus, but not in white matter or brainstem, were associated with higher risk of any stroke and ICH. (C) 2019 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据