期刊
AUTOPHAGY
卷 12, 期 11, 页码 1973-1983出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2016.1217381
关键词
autophagy; degradation; evolution; nuclear components; nucleus
类别
资金
- National Natural Science Foundation of China
- National Key Technologies RD Program
- Hubei Science Tech Project
- Chinese 111 Project Grant [B06018]
Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. Studies on autophagic degradation of cytoplasmic components have generated interest in nuclear autophagy. Although its mechanisms and roles have remained elusive, tremendous progress has been made toward understanding nuclear autophagy. Nuclear autophagy is evolutionarily conserved in eukaryotes that may target various nuclear components through a series of processes, including nuclear sensing, nuclear export, autophagic substrate encapsulation and autophagic degradation in the cytoplasm. However, the molecular processes and regulatory mechanisms involved in nuclear autophagy remain largely unknown. Numerous studies have highlighted the importance of nuclear autophagy in physiological and pathological processes such as cancer. This review focuses on current advances in nuclear autophagy and provides a summary of its research history and landmark discoveries to offer new perspectives.
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