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Kei Okatsu et al.
JOURNAL OF CELL BIOLOGY (2015)
Mechanism of phospho-ubiquitin-induced PARKIN activation
Tobias Wauer et al.
NATURE (2015)
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Michael Lazarou et al.
NATURE (2015)
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
Alban Ordureau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor
Yiyang Gong et al.
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CRISPR/Cas9-mediated endogenous protein tagging for RESOLFT super-resolution microscopy of living human cells
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BECN1 is involved in the initiation of mitophagy It facilitates PARK2 translocation to mitochondria
Vinay Choubey et al.
AUTOPHAGY (2014)
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
Agne Kazlauskaite et al.
BIOCHEMICAL JOURNAL (2014)
Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance
Lori Buhlman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain
Yusuke Kageyama et al.
EMBO JOURNAL (2014)
Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
Nicol Birsa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
Lesley A. Kane et al.
JOURNAL OF CELL BIOLOGY (2014)
The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy
Sven Geisler et al.
JOURNAL OF CELL SCIENCE (2014)
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
Alban Ordureau et al.
MOLECULAR CELL (2014)
Tools and techniques to measure mitophagy using fluorescence microscopy
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AUTOPHAGY (2013)
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
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CELL RESEARCH (2013)
Structure of the human Parkin ligase domain in an autoinhibited state
Tobias Wauer et al.
EMBO JOURNAL (2013)
A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
Kei Okatsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
Michael Lazarou et al.
JOURNAL OF CELL BIOLOGY (2013)
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
Shireen A. Sarraf et al.
NATURE (2013)
Genome engineering using the CRISPR-Cas9 system
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NATURE PROTOCOLS (2013)
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
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SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
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SCIENCE (2013)
The Ubiquitin Code
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ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation
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CELL (2012)
Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
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DEVELOPMENTAL CELL (2012)
Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode
Dorothea Becker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy
Yu Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Xinnan Wang et al.
CELL (2011)
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
Nickie C. Chan et al.
HUMAN MOLECULAR GENETICS (2011)
Parkin Interacts with Ambra1 to Induce Mitophagy
Cindy Van Humbeeck et al.
JOURNAL OF NEUROSCIENCE (2011)
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
Derek P. Narendra et al.
AUTOPHAGY (2010)
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Atsushi Tanaka et al.
JOURNAL OF CELL BIOLOGY (2010)
Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
Joo-Yong Lee et al.
JOURNAL OF CELL BIOLOGY (2010)
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler et al.
NATURE CELL BIOLOGY (2010)
Parkin occurs in a stable, non-covalent, similar to 110-kDa complex in brain
Cindy Van Humbeeck et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin
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HUMAN MOLECULAR GENETICS (2005)
PINK1 mutations are associated with sporadic early-onset parkinsonism
EM Valente et al.
ANNALS OF NEUROLOGY (2004)
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
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MOLECULAR & CELLULAR PROTEOMICS (2002)
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
H Shimura et al.
NATURE GENETICS (2000)