期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 26, 期 9, 页码 777-782出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41594-019-0288-9
关键词
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资金
- US Public Health Service Award [R01 GM025232]
- National Institutes of Health
Transcription regulation is critical to organism development and homeostasis. Control of expression of the 20,000 genes in human cells requires many hundreds of proteins acting through sophisticated multistep mechanisms. In this Historical Perspective, I highlight the progress that has been made in elucidating eukaryotic transcriptional mechanisms through an array of disciplines and approaches, and how this concerted effort has been driven by the development of new technologies.
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