期刊
NATURE REVIEWS GENETICS
卷 21, 期 1, 页码 44-62出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41576-019-0171-x
关键词
-
资金
- European Molecular Biology Organization LongTerm Fellowship
- Human Frontier Science Program Postdoctoral Fellowship
- NIH [CA206157, GM118066]
Cancer is driven by multiple types of genetic alterations, which range in size from point mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome instability, the process that gives rise to aneuploidy, can promote tumorigenesis by increasing genetic heterogeneity and promoting tumour evolution. However, much less is known about how aneuploidy itself contributes to tumour formation and progression. Unlike some pan-cancer oncogenes and tumour suppressor genes that drive transformation in virtually all cell types and cellular contexts, aneuploidy is not a universal promoter of tumorigenesis. Instead, recent studies suggest that aneuploidy is a context-dependent, cancer-type-specific oncogenic event that may have clinical relevance as a prognostic marker and as a potential therapeutic target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据