期刊
AUTOPHAGY
卷 12, 期 3, 页码 594-595出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2015.1135283
关键词
apoptosis; autophagy; Beclin1; Hippo pathway; NDR protein kinase
类别
资金
- MRC [G1002186] Funding Source: UKRI
- National Centre for the Replacement [NC/L000199/1] Funding Source: researchfish
- Medical Research Council [G1002186] Funding Source: Medline
- National Centre for the Replacement, Refinement and Reduction of Animals in Research [NC/L000199/1] Funding Source: Medline
We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy. By combining molecular, cell biological and genetic approaches, we show that STK38 promotes autophagosome formation in human cells and in Drosophila. Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, assist the co-ordination between autophagic and apoptotic events upon autophagy induction, hence proposing a role for STK38 in determining cellular fate in response to autophagic conditions.
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