期刊
NATURE IMMUNOLOGY
卷 20, 期 10, 页码 1360-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0472-4
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资金
- US National Institutes of Health [K22AI132937, P01AI056299, R37AI34495, R01HL11879]
- Evergrande Center for Immunologic Diseases
Follicular regulatory T (T-FR) cells have specialized roles in modulating follicular helper T (T-FH) cell activation of B cells. However, the precise role of T-FR cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still unclear due to a lack of specific tools. A T-FR cell-deleter mouse was developed that selectively deletes T-FR cells, facilitating temporal studies. T-FR cells were found to regulate early, but not late, germinal center (GC) responses to control antigen-specific antibody and B cell memory. Deletion of T-FR cells also resulted in increased self-reactive immunoglobulin (Ig) G and IgE. The increased IgE levels led us to interrogate the role of T-FR cells in house dust mite models. T-FR cells were found to control T(FH)13 cell-induced IgE. In vivo, loss of T-FR cells increased house-dust-mite-specific IgE and lung inflammation. Thus, T-FR cells control IgG and IgE responses to vaccines, allergens and autoantigens, and exert critical immunoregulatory functions before GC formation.
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