期刊
NATURE IMMUNOLOGY
卷 20, 期 9, 页码 1110-1128出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0444-8
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- National Health and Medical Research Council of Australia (NHMRC) [1113293, 1140126]
- Australian Research Council (ARC) [CE140100011]
- Cancer Council of Victoria
- NHMRC Senior Principal Research Fellowship [1117766]
- NHMRC ECF Fellowship [1160333]
- National Health and Medical Research Council of Australia [1160333, 1140126] Funding Source: NHMRC
In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative antigens presented by the major histocompatibility complex (MHC) class I-like protein MR1. MAIT cells use a limited T cell antigen receptor (TCR) repertoire with public antigen specificities that are conserved across species. They can be activated by TCR-dependent and TCR-independent mechanisms and exhibit rapid, innate-like effector responses. Here we review evidence showing that MAIT cells are a key component of the immune system and discuss their basic biology, development, role in disease and immunotherapeutic potential.
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