4.4 Article

Steroidal constituents isolated from the seeds of Withania somnifera

期刊

NATURAL PRODUCT RESEARCH
卷 35, 期 13, 页码 2205-2210

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TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1667351

关键词

Withania somnifera; Solanaceae; seed; withanolide glycoside; ergostanol glycoside; furostanol glycoside; cytotoxic activity

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Several new bioactive compounds were isolated from the seeds of Withania somnifera, with only one showing significant cytotoxic activity against human cancer cell lines. These compounds hold potential therapeutic value for the treatment of cancer.
A new withanolide glycoside (1), two new ergostanol glycosides (2 and 3), and a new furostanol glycoside (4), along with nine known steroidal derivatives (5-12) were isolated from the seeds of Withania somnifera. The structures of the new compounds were determined using spectroscopic analysis and hydrolysis. The cytotoxic activities of the isolated compounds were evaluated against Ca9-22 human gingival carcinoma cells, HSC-2 human mouth carcinoma cells, and HL-60 human promyelocytic leukemia cells. Only 12 exhibited cytotoxic activity against these cell lines with IC50 values of 0.38, 0.54, and 1.5 mu M, respectively.

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