期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 16, 页码 2748-2752出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1660656
关键词
Jatropha curcas; Euphorbiaceae; Rhamnofolane diterpenoid; Jatrophacine; Anti-inflammatory
资金
- Ministry of Science and Technology of the People's Republic of China under National Key RD Program [2018YFC1707000, 2018YFC1707900]
A new diterpenoid named jatrophacine (1) with an unusual skeleton was isolated from the roots of Jatropha curcas, along with eleven known diterpenoids. Compound 1 showed strong anti-inflammatory activity by inhibiting nitric oxide production in LPS-induced RAW 264.7 macrophages.
A new diterpenoid named jatrophacine (1), with an unusual 4,5-seco- rhamnofolane skeleton, was isolated from the roots of Jatropha curcas, together with eleven known diterpenoids. The structure of the new compound was elucidated through a detailed analysis of its 1 D- and 2 D-NMR spectra. The X-ray structure of jatrophol (2) is also presented. Anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that compound 1 strongly inhibited the production of nitric oxide (IC50 = 0.53 mu M).
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