期刊
NANO TODAY
卷 27, 期 -, 页码 28-47出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2019.05.004
关键词
Cancer immunotherapy; Smart nanosystems; Artificial antigen presenting cells; Cancer nanovaccine; Tumor microenvironment modulation; Combination therapy
资金
- Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- National Natural Science Foundation of China (NSFC) [81471689, 81771873, 91859207]
Immunotherapy (e.g., checkpoint blockade, adoptive T cell therapy, cancer vaccine) has emerged as one of the most important treatment modalities for cancer in the past two decades. While these approaches are promising, the response rates observed in clinical trials are less than 30% due to tumor heterogeneity and complexity of the tumor microenvironment. Smart nanosystems have the potential to address some of the limitations associated with immunotherapy. Herein, we review applications of nanosystem-mediated immunotherapy for functional T cell activation, including formation of artificial antigen presenting cells, cancer nanovaccination, tumor microenvironment modulation, and combination therapy. Finally, we propose areas of research for the future development of nanosystem-mediated cancer immunotherapy. (C) 2019 Published by Elsevier Ltd.
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