期刊
NANO LETTERS
卷 19, 期 9, 页码 6244-6254出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b02296
关键词
platinum nanorod; clinical; brain; neural interface; neurotechnology
类别
资金
- CINT, U.S. Department of Energy, Office of Basic Energy Sciences User Facility at Los Alamos National Laboratory [DE-AC52-06NA25396]
- Sandia National Laboratories [DE-AC04-94AL85000]
- National Science Foundation [ECCS-1542148]
- NSF-CAREER [1351980]
- NSF CMMI award [1728497]
- NSF-ECCS EAGER [1743694]
- NIH/NINDS [U01-099700, 3R01MH111359]
- NIH/NEI [R01-029022]
- Center for Brain Activity Mapping at UCSD
- UC-National Lab in-residence graduate fellowship
- Center for Design-Enabled Nano fabrication (C-DEN) at the University of California
- Center for Integrated Nanotechnologies (CINT)
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1351980] Funding Source: National Science Foundation
The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibility for high performance neurotechnologies. PtNR arrays record brain activity with cellular resolution from the cortical surfaces in birds and nonhuman primates. Significantly, strong modulation of surface recorded single unit activity by auditory stimuli is demonstrated in European Starling birds as well as the modulation of local field potentials in the visual cortex by light stimuli in a nonhuman primate and responses to electrical stimulation in mice. PtNRs record behaviorally and physiologically relevant neuronal dynamics from the surface of the brain with high spatiotemporal resolution, which paves the way for less invasive brain-machine interfaces.
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