期刊
NANO LETTERS
卷 19, 期 10, 页码 6772-6780出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b01716
关键词
Yolk-shell nanostructure; gold nanostar@ZIF-8; NIR-II window; photothermal therapy; chemotherapy
类别
资金
- Science and Technology Cooperation Fund between Chinese and Australian Governments [2017YFE0132300]
- National Natural Science Foundation of China [NSFC 51720105015, 51828202, 51628201, 51572257, 21728101, 51929201]
- CAS-Croucher Funding Scheme for Joint Laboratories [CAS18204]
- Chinese Academy of Sciences [YZDYSSWJSC018]
- Science and Technology Development Plan of Jilin Province [20170414003GH, 20170101187JC]
Light-sensitive yolk-shell nanoparticles (YSNs) as remote-controlled and stimuli-responsive theranostic platforms provide an attractive method for synergistic cancer therapy. Herein, a kind of novel stimuli-responsive multifunctional YSNs has been successfully constructed by integrating star-shaped gold (Au star) nanoparticles as the second near-infrared (NIR-II) photothermal yolks and biodegradable crystalline zeolitic imidazolate framework-8 (ZIF-8) as the shells. In this platform, a chemotherapeutic drug (doxorubicin hydrochloride, DOX) was encapsulated into the cavity, which can show the behavior of controlled release due to the degradation process of ZIF-8 in the mildly acidic tumor microenvironment. Upon the 1064 nm (NIR-II biowindow) laser irradiation, gold nanostar@ZIF-8 (Au@MOF) nanoparticles exhibited outstanding synergistic anticancer effect based on their photothermal and promoted cargo release properties. Moreover, the strong NIR region absorbance endows the Au@MOF of NIR thermal imaging and photoacoustic (PA) imaging properties. This work contributes to design a stimuli responsive all-in-one nanocarrier that realizes bimodal imaging diagnosis and chemo-photothermal synergistic therapy.
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