Polymer biodegradable coatings as active substance release systems for urological applications

Catheter-associated urinary tract infections are the result of catheterization of the bladder. The risk of infection is directly proportional to the length of the bladder catheterization. Bacteria cells have the ability to adhere and create the biofilm on the surface of catheter materials. Bacteria's biofilm is an extremely beneficial environment of existence for microorganisms. Microorganisms that are an integral part of the biofilm are characterized by a higher resistance to antimicrobial agents compared to the planktonic form of bacteria. The previous treatment of urinary tract infections presupposes the necessity of the oral administration of large amounts of antimicrobial agents. An alternative may be the use of antimicrobial and antiadhesion coatings on the surface of the catheters. These coatings may allow target drug delivery and contribute to dose reduction and improved drug availability. In this study, antimicrobial coatings from biodegradable polymers with clindamycin were evaluated. The antimicrobial activity of the prepared coatings against selected bacterial strains was determined. The high-performance liquid chromatography-mass spectrometry technique was applied for the analysis of the drug release from antimicrobial coatings. [GRAPHICS] .