期刊
MOLECULES
卷 24, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules24193558
关键词
1-aryl-6-azaisocytosine; 1; 2; 4-triazine; condensed 1; 2; 4-triazine; fused azaisocytosines; cyclization of arylhydrazones
资金
- Palacky University [IGA_PrF_2019_027, IGA_LF_2019_019]
- TACR [TE02000058]
A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles 4 is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide 2 and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides 3. The 6-azaisocytosines 4 were studied with respect to tautomeric equilibrium and the transformation of functional groups, and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-c]-[1,2,4]triazine 8 and the 1,2,4-triazino[2,3-a]quinazolines 9-12.
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