期刊
MOLECULES
卷 24, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/molecules24173196
关键词
Sinopodophyllum hexandrum; prenylated flavonoid; cytotoxic activity
资金
- National Natural Science Foundation of China [31300284]
- Basic Science Foundation of Henan University of Chinese Medicine [2014KYYWF-QN26]
- Science and Technology Innovation Talent Support Scheme of Henan University of Chinese Medicine [2016XCXRC01]
- Scientific and Technological Key Project in Henan Province [192102310438]
- Henan Key Laboratory of Zhang Zhong-jing Formulae and Herbs for Immunoregulation [kfkt201701]
Sixteen new prenylated flavonoids, sinoflavonoids P-Z (1-11) and sinoflavonoids NA-NE (12-16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17-24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, H-1-NMR, C-13-NMR, HSQC, HMBC). The cytotoxic activities of compounds 1-18, 20, and 22 were evaluated by MTT assay. Compound 6 showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC50 values of 6.25 and 3.83 mu M, respectively.
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