期刊
MOLECULES
卷 24, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/molecules24162909
关键词
spirooxindoles; isoxazolidines; MDM2-p53 inhibition; indane derivatives
资金
- Italian Ministry of University and Scientific Research (MIUR)
- University of Calabria
- MINECO [CTQ2016-76155-R]
- FEDER Program (Madrid, Spain) [CTQ2016-76155-R]
- Gobierno de Aragon (Zaragoza, Spain. Biological & Computational Chemistry Group) [E34_R17]
Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign microwave technology. The contemporary presence of various structural groups that are individually active scaffolds of different typology of drugs, has directed us to speculate that these compounds may act as inhibitors of MDM2-p53 interaction. Therefore, both computational calculations and antiproliferative screening against A549 human lung adenocarcinoma cells and human SH-SY5Y neuroblastoma cells were carried out to support this hypothesis.
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