期刊
MOLECULES
卷 24, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/molecules24152855
关键词
Phyllanthus orbicularis; C-glycoside; flavonoid; natural products; traditional medicine; Cuba; Phyllanthus chamacristoides; chromatography; mass spectrometry; NMR; circular dichroism; stereochemistry; Fideloside; cytokines; anti-inflammatory activity
资金
- Leibniz-DAAD grant
- Leibniz SAS (Leibniz Research Alliance BCB interaction fund)
Phyllanthus orbicularis (Phyllanthaceae) is an endemic evergreen tropical plant of Cuba that grows in the western part of the island and is used in traditional medicine as an infusion. The aqueous extract of this plant presents a wide range of pharmacological activitiessuch as antimutagenic, antioxidant and antiviral effects. Given the many beneficial effects and the great interest in the development of new pharmacological products from natural sources, the aim of this work was to investigate the phytochemistry of this species and to elucidate the structure of the main bioactive principles. Besides the presence of several known polyphenols, the major constituent was hitherto not described. The chemical structure of this compound, here named Fideloside, was elucidated by means of HR-ESIMS/MSn, 1D/2D NMR, FT-IR, and ECD as (2R,3R)-(-)-3',4 ',5,7-tetrahydroxydihydroflavonol-8-C-beta-D-glucopyranoside. The compound, as well as the plant aqueous preparations, showed promising bioactive properties, i.e., anti-inflammatory capacity in human explanted monocytes, corroborating future pharmacological use for this new natural C-glycosyl flavanonol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据