期刊
MOLECULES
卷 24, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules24193437
关键词
eushearilide; demethyl congener; total synthesis; lactonization; MNBA; antimicrobial activity
资金
- Ministry of Education, Science, Sports, and Culture, Japan
A novel stereoisomer of eushearilide, 23-demethyleushearilide, was synthesized, and the structure-activity relationships of this compound along with known eushearilide stereoisomers were investigated in order to design novel lead compounds for the treatment of fungal infections. It was discovered that all of these congeners, together with the natural product, exhibited a wide range of antimicrobial activity against not only fungi but also against bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).
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