期刊
MOLECULAR PHARMACEUTICS
卷 16, 期 9, 页码 3814-3822出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.9b00416
关键词
pancreatic cancer; Nab-paclitaxel; microbubble; ultrasound; sonoporation
资金
- CANCEN
- FARE-SNFGE
- Ligue Contre le Cancer
- Inserm
- CanceropOle Grand-Ouest
A combination of microbubbles (MBs) and ultrasound (US) is an emerging method for noninvasive and targeted enhancement of anti-cancer drug uptake. This method showed an increase local drug extravasation in tumor tissue while reducing the systemic adverse effects in various tumor models. The present study aims to evaluate the effectiveness of this approach for Nab-paclitaxel delivery in a pancreatic tumor model. US and MBs of different types in combination with Nab-paclitaxel showed a loss in cell viability of pancreatic cancer cells in comparison with Nab- paclitaxel treatment alone in in vitro scenario. The in vivo data revealed that US and MBs in combination with Nab-paclitaxel induced a significant decrease in the tumor volume in a subcutaneous pancreatic adenocarcinoma mouse model in comparison to tumors treated with Nab-paclitaxel alone. The postmortem anatomopathological analyses of tumor tissues partially confirmed these results. In conclusion, this study demonstrates that MB-assisted US is a relevant technology to increase the therapeutic effectiveness of Nab-paclitaxel in a pancreatic cancer model.
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