期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 63, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.201801187
关键词
butyrate; constipation; diversity; gut microbiota; metabolites
资金
- National Nature Science Foundation of China [U1501214]
- Tianjin One Belt and One Road Technological Innovation Project [18PTZWHZ00080]
- National Key Research and Development Program [2016YFD0400401-2, 2016YFD0400104-4]
- Australian Research Council Industrial Transformation Training Centre for Functional Grains, Charles Sturt University, Australia
ScopeThe characteristics of gut microbiota and host metabolism are hypothesized to be associated with constipation status, but the regulation mechanism is not fully understood. Thus, the current study investigates the effect of constipation symptoms on gut functionality following the modulation of gut microbiota and metabolites via dietary fiber intervention. Methods and resultsConstipation causes a significantly reduced short-chain fatty acids (SCFAs) production and a higher level of iso-butyrate. The feces of constipated people are characterized with inhibited Faecalibacterium, Ruminococcaceae and Roseburia abundance. Desulfovibrionaceae is identified to be an important endotoxin producer in constipated patients, and a butyrate-enriched SCFAs profile achieved by dietary fiber supplement accelerates gastrointestinal transit and increases the thickness of the mucosal layer, possibly through triggering the secretion of colonic hormones and enhancing the expression of tight junction proteins for maintaining intestinal barrier integrity. More importantly, an interacting regulatory mechanism among SCFAs, in particular butyrate and propionate, may be involved in signaling between the microbiome and host cells in the colon. ConclusionGut microbiota, characterized with enriched butyrate-producing and depressed Desulfovibrionaceae bacteria, attenuates constipation symptoms through promoting intestinal hormones secretion and maintaining gut barrier integrity.
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