期刊
MOLECULAR CELL
卷 76, 期 2, 页码 320-328出版社
CELL PRESS
DOI: 10.1016/j.molcel.2019.08.025
关键词
-
资金
- Beijing Municipal Science and Technology Commission [Z181100001318001]
Germline cells are the beginning of new individuals in multicellular animals, including humans. Our understanding of these cell types is limited by the difficulty of analyzing the precious and heterogeneous germline tissue samples. The rapid development of single-cell sequencing technologies provides a chance for comprehensive profiling of the omics dynamics of human germline development. In this review, we discuss progress in analyzing the development of human germline cells, including preimplantation and implantation embryos, fetal germ cells (FGCs), and adult spermatogenesis by single-cell transcriptome and epigenome sequencing technologies.
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