期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 21, 页码 4787-4792出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.07.018
关键词
Reactive carbonyl; Ferroptosis; Covalent; Erastin; Metabolic stability
资金
- Columbia Chemistry NMR core facility (NSF) [CHE 0840451]
- Columbia Chemistry NMR core facility (NIH) [1S10RR025431-01A1]
Introducing a reactive carbonyl to a scaffold that does not otherwise have an electrophilic functionality to create a reversible covalent inhibitor is a potentially useful strategy for enhancing compound potency. However, aldehydes are metabolically unstable, which precludes the use of this strategy for compounds to be tested in animal models or in human clinical studies. To overcome this limitation, we designed ketone-based functionalities capable of forming reversible covalent adducts, while displaying high metabolic stability, and imparting improved water solubility to their pendant scaffold. We tested this strategy on the ferroptosis inducer and experimental therapeutic erastin, and observed substantial increases in compound potency. In particular, a new carbonyl erastin analog, termed IKE, displayed improved potency, solubility and metabolic stability, thus representing an ideal candidate for future in vivo cancer therapeutic applications. (C) 2015 Published by Elsevier Ltd.
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