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Combined R2*and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease
Guangwei Du et al.
MOVEMENT DISORDERS (2011)
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Eric Karran et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice
Giada Sebastiani et al.
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Hepcidin Is Involved in Iron Regulation in the Ischemic Brain
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PLOS ONE (2011)
Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
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CELL (2010)
Role of hepcidin in murine brain iron metabolism
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Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders
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PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
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Unraveling of the E-helices and Disruption of 4-Fold Pores Are Associated with Iron Mishandling in a Mutant Ferritin Causing Neurodegeneration
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Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
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Expression of iron-related genes in human brain and brain tumors
Milla M. Hanninen et al.
BMC NEUROSCIENCE (2009)
Altered Iron Metabolism Is Part of the Choroid Plexus Response to Peripheral Inflammation
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ENDOCRINOLOGY (2009)
The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes
Xiao Hu Ge et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2009)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial (vol 7, pg 779, 2008)
L. Lannfelt et al.
LANCET NEUROLOGY (2009)
Chelation Therapy for Neurodegenerative Diseases
Silvia Bolognin et al.
MEDICINAL RESEARCH REVIEWS (2009)
Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain
Qin Wang et al.
ENDOCRINOLOGY (2008)
Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration
Martin A. Baraibar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Midbrain iron content in early Parkinson disease - A potential biomarker of disease status
W. R. Wayne Martin et al.
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Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease:: a phase IIa, double-blind, randomised, placebo-controlled trial
Lars Lannfelt et al.
LANCET NEUROLOGY (2008)
Brain iron metabolism: Neurobiology and neurochemistry
Ya Ke et al.
PROGRESS IN NEUROBIOLOGY (2007)
Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents
Silvia Mandel et al.
PROGRESS IN NEUROBIOLOGY (2007)
The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells
Tracy R. Daniels et al.
CLINICAL IMMUNOLOGY (2006)
Is ferroportin-hepcidin signaling altered in restless legs syndrome?
Stacey L. Clardy et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)
Distribution of the iron-regulating protein hepcidin in the murine central nervous system
S. Zechel et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
Longitudinal assessment of Alzheimer's β-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging
Niels Braakman et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2006)
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
A Gaeta et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Effects of development and iron status on ceruloplasmin expression in rat brain
YZ Chang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain
Y Ke et al.
NEUROBIOLOGY OF AGING (2005)
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
S Rivera et al.
BLOOD (2005)
Neurodegenerative disease and iron storage in the brain
M Thomas et al.
CURRENT OPINION IN NEUROLOGY (2004)
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
G Nicolas et al.
NATURE GENETICS (2003)
Iron misregulation in the brain: a primary cause of neurodegenerative disorders
Y Ke et al.
LANCET NEUROLOGY (2003)
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
D Kaur et al.
NEURON (2003)
Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome.
SJ Hayflick et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?
D Kaur et al.
AGING CELL (2002)
Transferrin/transferrin receptor-mediated drug delivery
HY Li et al.
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The role of the transferrin-transferrin-receptor system in drug delivery and targeting
HY Li et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers
CN Roy et al.
HUMAN MOLECULAR GENETICS (2001)
A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
B Zhou et al.
NATURE GENETICS (2001)
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
G Nicolas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
CH Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
C Pigeon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Brain iron transport and neurodegeneration
ZM Qian et al.
TRENDS IN MOLECULAR MEDICINE (2001)
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
T LaVaute et al.
NATURE GENETICS (2001)
A novel mammalian iron-regulated protein involved in intracellular iron metabolism
S Abboud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
A Donovan et al.
NATURE (2000)
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
AT McKie et al.
MOLECULAR CELL (2000)
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
A Krause et al.
FEBS LETTERS (2000)