期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 23, 页码 5477-5480出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.10.083
关键词
Antibiotic resistance; Vancomycin; Vancomycin-resistant bacteria; Cell wall biosynthesis inhibition; Antibacterial activity
资金
- Department of Science and Technology (DST), Govt. of India [SR/S2/RJN-43/2009]
- CSIR
Antibiotic-resistant superbugs such as vancomycin-resistant Enterococci (VRE) and Staphylococci have become a major global health hazard. To address this issue, we synthesized vancomycin aglycon dimers to systematically probe the impact of a linker on biological activity. A dimer having a pendant lipophilic moiety in the linker showed similar to 300-fold more activity than vancomycin against VRE. The high activity of the compound is attributed to its enhanced binding affinity to target peptides which resulted in improved peptidoglycan (cell wall) biosynthesis inhibition. Therefore, our studies suggest that these compounds, prepared by using facile synthetic methodology, can be used to combat vancomycin-resistant bacterial infections. (C) 2015 Elsevier Ltd. All rights reserved.
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