期刊
AUTOIMMUNITY REVIEWS
卷 15, 期 7, 页码 695-703出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2016.03.004
关键词
Primary Sjogren's syndrome; Biomarkers; Lymphoma; Systemic manifestations; Predictors
类别
Primary Sjogren's syndrome (pSS) is a complex autoimmune disease with distinct clinical phenotypes and variable outcomes. The systemic form of the disease is characterized by immune complex mediated manifestations and is complicated by lymphoma as a result of a polyclonal B cell hyperactivity that is evolving into B cell malignancy. In the past decades, well-established clinical and serological markers have been described in the literature to identify high-risk patients and to predict lymphoma development. However, specific biologic treatments have proven ineffective to control the disease. Significant research effort has been made to reveal the major underlying biological events in this subgroup and identify biomarkers for early diagnosis, prognosis and response to treatment. In this review, we summarize the current data for the proposed histological, molecular and genetic biomarkers. (C) 2016 Elsevier B.V. All rights reserved.
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