期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 16, 页码 3112-3116出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.06.017
关键词
Red ginseng; Ginsenosides; Melanogenesis; Tyrosinase inhibitor
资金
- National Key Technology R&D Program of China [2011BAI07B08]
- Guiding Foundation of Pharmaceutical Industry Development Project of Jilin Province [20150311023YY]
During a search for novel melanogenesis inhibitors originating from nature sources, four new ginsenosides, including three dammarane-type triterpenoid saponins, 20(S)-ginsenoside-Rf-1a (1), 20Z-ginsenoside-Rs(4) (2), 23-O-methylginsenoside-Rg(11) (3), and one oleanane-type saponin, ginsenoside-Ro-6 '-O-butyl ester (4) were isolated from red ginseng (the steamed ginseng) to evaluate their protective effects against melanogenesis. Compounds 2 and 3 exhibited potent inhibitory effects against both melanin synthesis and tyrosinase activity in a dose-dependent manner in the alpha-MSH-stimulated B16 melanoma cells, and were more potent than the positive control arbutin, a well-known tyrosinase inhibitor. The results indicated that just the two carbon-20(22) double-bond-type ginsenosides showed strong inhibiting activity on melanogenesis through reducing tyrosinase activity. Thus, ginsenosides with such similar chemical structure in red ginseng may be potential natural products as tyrosinase inhibitors against malignant melanoma. (C) 2015 Elsevier Ltd. All rights reserved.
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