期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 16, 页码 3281-3284出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.05.076
关键词
Carbonic anhydrase; Sulfonamide; Tumor-associated isoform; Selective inhibitor
资金
- Regione Autonoma della Sardegna (RAS) [LR 7/2007 CRP-24915]
A series of 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides was synthesised and the activity of the new compounds as inhibitors of hCA I, II, IX, and XII was evaluated. These new derivatives exhibited some peculiarities with respect to previously reported sulfonamide based inhibitors of CA. We observed that the nature of the substituents in the position 3 and 4 of the dihydro- thiazole ring was relevant in determining both activity and selectivity profiles. (C) 2015 Elsevier Ltd. All rights reserved.
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