期刊
MARINE DRUGS
卷 17, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/md17100563
关键词
deep-sea sediment-derived fungus; Aspergillus versicolor; bisabolane-type sesquiterpenoids; monoterpenoids; antimicrobial activity
资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA22050401]
- Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2016ASKJ14]
- National Natural Science Foundation of China [31700043]
- China Postdoctoral Science Foundation [2016LH00033, 2017M612358, 2017M612360]
- Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences [KEXUE2018G28]
- Taishan Scholar Project from Shandong Province
- Shandong Provincial Natural Science Foundation [ZR2017BB073]
Two new antimicrobial bisabolane-type sesquiterpenoid derivatives, ent-aspergoterpenin C (compound 1) and 7-O-methylhydroxysydonic acid (2), and two new butyrolactone-type monoterpenoids, pestalotiolactones C (3) and D (4), along with a known monoterpenoid pestalotiolactone A (5) and four known bisabolane sesquiterpenoids (6-9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of the new compounds 1-4 were determined by the combination of NOESY and TDDFT-ECD calculations and X-ray crystallographic analysis. Additionally, we first determined and reported the absolute configuration of the known monoterpenoid pestalotiolactone A (5) through the X-ray crystallographic experiment. All of these isolated compounds were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2, 6 and 9 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio anguillarum and V. harveyi, with MIC values ranging from 1.0 to 8.0 mu g/mL.
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